Machining of Complex Sculptured Surfaces ILO The need for a handbook Jr The need for a handbook on the use of synthetic substrates for assay of proteases of the coagulation and fibrinolytic systems became evident several years ago during the activities of the Subcommittee on Synthetic Substrates of the International Committee on Thrombosis and Haemo stasis (lCTH) In many cases it is unavoidable that nanoparticles are released into the environment The traditional technology employed in the manufacture of moulds and dies combined conventional milling and electro discharge machining (EDM) but this has been replaced with high speed milling (HSM) which has been applied in roughing Machining of Complex Sculptured Surfaces provides recent information on machining of complex sculptured surfaces including modern CAM systems and process planning for three and five axis machining as well as explanations of the advantages of HSM over traditional methods ranging from work piece precision and roughness to manual polishing following machining operations